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Nat Prod Commun. Evid Based Complement Alternat Med. Epub Nov National Library of Medicine U. National Institutes of Health U. Department of Health and Human Services. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Dietary Supplement: UA group. Phase 2 Phase 3. Study Type :. Actual Enrollment :. Study Start Date :. Actual Primary Completion Date :. Actual Study Completion Date :. Sharma, H. Tuli, S. Punia, and A. Toglia and K. Donat, G. Scott, S. Gentleman, and M. Lee, S. Gajavelli, M. Spurlock et al.

Liddelow, K.

Oxidative Medicine and Cellular Longevity

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Increased muscle growth and fat loss with Ursolic Acid? | Alivebynature - All about NAD+

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  • Ursolic acid.
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Manya, and T. Cararo-Lopes, C. Mazucanti, C. Scavone, E. Kawamoto, and D. Kurosu, M. Yamamoto, J.

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Ingredient of the Week: Ursolic Acid

Loesche, A. Lucas et al. Syed, E. Beurel, D. Loewenstein et al. Leng, K. Zhuang, Z. Liu et al. Ma, K. Demin, T. Kolesnikova et al. Limphaibool, and M. Fourrier, G. Singhal, and B. Chan, F. Cathomas, and S. Tolkien, S. Bradburn, and C. Fedoce, F. Ferreira, R. Bota, V. Bonet-Costa, P. Sun, and K. Lee et al. Based on studies with hairless mice, Lim et al. They concluded that both acids have potential for use as agents to promote epidermal permeability barrier function. In , Soo et al.

They concluded that ursolic acid may merit attention for the prevention of UVA-induced photoaging. Three years earlier, Yarosh et al. Over an day period, clinical tests with the ursolic acid—containing liposome Merotaine revealed increases in the ceramide content in human skin. This new study also demonstrated that ursolic acid liposomes raise ceramide levels in normal human epidermal keratinocytes, in contrast to the effects of retinoic acid, earlier shown to reduce such levels.

They concluded that ursolic acid liposomes show promise for use alone or in combination to replenish or maintain cutaneous ceramide and collagen levels. Ursolic acid is a compelling ingredient. I especially will be interested in the results of ongoing human clinical trials of this triterpenoid for treating cancer and skin wrinkles. As it is, ursolic acid is known to exert significant inhibitory activity against tumor formation and tumor cell viability in the laboratory. Given its wide range of biologic activity, and some promising cutaneous results, there is reason to believe that ursolic acid has the potential to play an increasingly useful role in topical skin care agents and dermatologic practice.

J Dermatol. Folia Histochem Cytobiol. J Cosmet Dermatol. J Enzyme Inhib Med Chem. J Biomed Biotechnol. Biosci Biotechnol Biochem. J Ethnopharmacol.