For that reason, it is important that interventional trials should continue to carefully review their data to ensure that persons whose laboratory values fall within the new ranges are indeed at no greater risk as compared to the current tables. Our reference intervals, in addition to the existing intervals could be used for comparison by the Botswana Ministry of health in establishing Botswana population based reference ranges for standardization of laboratory diagnosis.
The authors would like to thank the TDF2 participants for volunteering to participate in this study, the Botswana Ministry of Health and the US centers for disease control and prevention for approving this study as well as the TDF2 study team especially the HIV prevention research lab team that was responsible for testing and reporting the results presented in the paper.
Disclaimer: The findings and conclusions in this article are those of the authors and do not necessarily represent the views of the U.
Centers for Disease Control and Prevention. Use of trade names is for identification purposes only and does not constitute endorsement by the U. Performed the experiments: TMS. Reviewed the manuscript: RN. Browse Subject Areas?
Click through the PLOS taxonomy to find articles in your field. Abstract Introduction Accurate clinical laboratory reference values derived from a local or regional population base are required to correctly interpret laboratory results. Results Out of screened participants, met eligibility criteria for participation in study and were included in the analysis. Conclusion Our reference values illustrate the differences in hematological and biochemical analyte ranges between African and Western populations.
Gray, University of Cape Town, South Africa Received: October 11, ; Accepted: February 28, ; Published: April 8, This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. Introduction Clinical laboratory testing is the most widely used medical decision-making tool  and is crucial for disease screening, diagnosis, monitoring disease progression and treatment efficacy. This study is registered with clinicaltrial. Reference Range Analysis Of the TDF2 study participants who underwent chemistry and hematology testing, 73 were excluded from analysis due to factors that rendered them ineligible for study participation and could have affected their suitability for reference values.
Download: PPT. Figure 1. Table 1. Blood Collection and Testing Methodologies Blood specimens were collected in the clinics at each study site and transported in coolers from the on-site clinic laboratories to the off-site laboratories which were a 5 to10 minute drive away. Statistical Analysis The Clinical Laboratory Standards Institute CLSI  recommends a sample size of at least values for non-parametric reference intervals and for parameters not influenced by gender 60 females and 60 males. Results Characteristics of Study Population Of the screened participants, Hematological and Biochemistry Parameters The analysis results are presented in Table 2.
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Table 2. Table 3. Comparison of the calculated Botswana TDF2 screened cohort reference intervals with the reference intervals used in Botswana and other African countries. Acknowledgments The authors would like to thank the TDF2 participants for volunteering to participate in this study, the Botswana Ministry of Health and the US centers for disease control and prevention for approving this study as well as the TDF2 study team especially the HIV prevention research lab team that was responsible for testing and reporting the results presented in the paper.
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This information is not designed to replace a physician's independent judgment about the appropriateness or risks of a procedure for a given patient. Factor IX. Factor V. Factor VII. Factor VIII. Factor X. Factor XI. Factor XII. After overnight suppression test. C-reactive protein, highly sensitive hsCRP. Erythrocyte sedimentation rate ESR :.
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